Enzyme immunoassay with antigens produced by recombinant techniques for the detection of IgG and IgA antibodies against the coronavirus SARS-CoV-2 in human serum or plasma.

In December 2019 began in the city of Wuhan, capital of Hubei in China, a pandemic spread of the disease caused by a new variant of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV). The newly discovered variant is called SARS-CoV-2 and is closely related to SARS-CoV(-1). SARS coronaviruses spread primarily via droplets in exhaled air to transmit from person to person.

Symptoms range from fever, cough and dyspnoea to pneumonia and acute respiratory distress syndrome and ultimately death in persons with comorbidities. Since the end of 2020, several vaccines against SARS-CoV-2 have been approved, most of which target the spike protein of the virus that mediates contact with the host cell.

According to the German Robert Koch Institute, infected persons usually develop detectable antibodies in the second week after the onset of symptoms. A seroconversion or a significant increase in titer for IgG antibodies in the same test system can indicate an acute infection, especially in combination with corresponding symptoms. Thus, serological detection of antibodies serves as an ideal addition to molecular detection, which is recommended for acute diagnostics. Furthermore, the detection of IgG antibodies is a clear indication of pathogen contact and can detect a past infection and can be used for epidemiological studies.

Product advantages for your benefit

• Very high sensitivity and specificity due to the use of highly purified recombinant nucleocapsid antigen
• Easy test procedure in the automatable ELISA screening format; quantitative results
• Identical processing as well as uniform and interchangeable reagents for all MIKROGEN recomWell ELISA
• Break-aparts: single sample examination possible
• CE label: The recomWell SARS-CoV-2 IgG, IgA tests meet the high standards of the European directive 98/79/EC on in vitro diagnostic medical devices

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