Human Herpesvirus Six (HHV-6) is one of the eight known viruses that are members of the human herpervirus family. It causes the disease Roseola.
HHV-6 re-activation causes severe disease in transplant recipients and can lead to graft rejection, often in consort with other betaherpesviridae. Likewise in HIV/AIDS, HHV-6 re-activations cause disseminated infections leading to end organ disease and death.

HHV-6 has been reported in multiple sclerosis patients (1) and has been implicated as a co-factor in several other diseases, including chronic fatigue syndrome (2), fibromyalgia, etc.

(1) Alvarez-Lafuente R, Martín-Estefanía C, de las Heras V, et al. (February 2002). "Prevalence of herpesvirus DNA in MS patients and healthy blood donors". Acta Neurol. Scand. 105 (2): 95–9.

(2) Komaroff AL. (December 2006). "Is human herpesvirus-6 a trigger for chronic fatigue syndrome". J Clin Virol. 37 (Suppl 1): S39–46.

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