CLIA ENA Screen plus
in human serum or plasma.
ENA Screen is a serology test to detect IgG autoantibodies against extractable nuclear antigens (ENAs), which is a subgroup of antinuclear antibodies (ANAs) which do not readt with chromatin. ENA screen is usually used following a positive result in an antinuclear antibody (ANA) test.
ENAs are mainly recognized by sera from patients with systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), systemic sclerosis, myositis, Sjögren's, scleroderma, polymyositis, and rheumatoid arthritis. Classical autoantigens detectable in sera from SLE patients are Smith-Protein (Sm), ribonucleoproteins (RNP), Robert-Antigen/Sjögren's A (Ro/SSA), and Lane-Antigen/Sjögren's B (La/SSB); they are usually completed with Scl-70 and Jo-1 antigens. The use of the centromere B antigen is an extension of the standard antigen set.
Products
| Product | Size | Article no. | |
|---|---|---|---|
|
100 Tests
|
Article no.: 71015 | Request |
Advantages
- Detection of IgG antibodies to extractable nuclear antigens and centromere B (ENA)
- Differential diagnosis of systemic autoimmune diseases
- Monitoring autoimmune disease progression
- Intended for human serum and citrate plasma
- A mixture of native and recombinant antigens is used: Ro52/SS-A, Ro60/SS-A, La/SS-B, RNP-A, RNP-C, RNP 68, Sm, Scl-70, Jo-1, and centromere B
- The kits are CE-IVD certified and intended for professional use
- For each CLIA kit a corresponding control set is available
| Assay time | 30 min |
| Assay stability | 30 days in-board-stability / in-use-stability until the expiration date at storage temperature 2-8 °C |
| Sample matrix | Serum, Plasma |
| Sample volume | 10 µL |
| Sample stability | 7 days at 2-8 °C, 24 months at -20 °C |
| Measuring range | 3 - 320 U/ml |
| Assay/kit content | Reagent Cartridge with specific reagents for the assay, magnetic particles, calibrators |