CLIA IL-6
Interleukin 6 (IL-6) is a cytokine that plays important roles in both innate and adaptive immunity. IL-6 is upregulated in patients with infection, sepsis, and septicemia and indicates an ongoing inflammatory response. Elevated IL-6 concentrations appear to correspond with the severity of sepsis. IL-6 upregulation is associated with more localized infections but it is also increased in numerous chronic inflammatory disorders, such as systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease.
IL-6 is not diagnostic for any specific disease and IL-6 levels must be interpreted within the clinical context of the patient.
In neonatology and paediatrics, IL-6 serves as an early marker for sepsis and septic shock, as the increase can occur even before clinical symptoms appear. In sepsis and SIRS (systemic inflammatory response syndrome), IL-6 is suitable for prognosis, risk stratification and assessment of organ failure.
In severe cases of COVID-19, IL-6 is a sensitive early indicator of an impending cytokine storm reaction.
Advantages
- Aid to identify the development of sepsis or SIRS in adult patients
- Illness severity prediction and death prognosis in septic patients
- Early identification of bacterial sepsis in infants
- Evaluation of patients with suspected localized infection
- Evaluation of patients with suspected systemic infection
- The kits are CE-IVD certified and intended for professional use
- For each CLIA kit a corresponding control set is available
| Assay Time | 17 min |
| Assay stability | 30 days on-board-stability / in-use-stability until the expiration date at storage temperature 2-8 °C |
| Sample Matrix | Serum |
| Sample volume | 34 µl |
| Measuring range | 5-5000 ng/l |
| Assay/kit content | Reagent Cartridge with specific reagents for the assay, magnetic particles, calibrators |