CLIA Leptin

Leptin, together with adiponectin, is one of the key adipokines produced by adipose tissue; they play an essential role in energy metabolism, inflammatory processes and insulin sensitivity. Their concentrations and their ratio serve as biomarkers for the early detection of metabolic dysfunction and cardiometabolic risks.

Leptin is produced in white adipose tissue and regulates appetite and energy expenditure via the hypothalamus. However, leptin resistance often develops in obesity, meaning that even very high leptin levels are no longer utilised effectively by the body.

This condition is associated with:

- impaired central regulation of appetite and satiety

- increased risk of high blood pressure (leptin activates the sympathetic nervous system)

- pro-inflammatory effects – leptin stimulates the production of IL-6 and CRP

- development of insulin resistance and atherogenesis

The adiponectin-leptin ratio (Adp/Lep) is considered a sensitive marker of adipose tissue function. A low ratio indicates insulin resistance and an increased risk of metabolic syndrome. It enables earlier risk detection than traditional markers and supports personalised prevention and treatment, including in children and adolescents.

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