CLIA SS-B
SS-B/La antigen is a phosphoprotein with molecular weight 48 kDa localized mostly in a complex with various RNA molecules in both the cell nucleus and the cytoplasm.
Autoantibodies against SS-B/La are rarely found by themeselves. They are more frequently associated with antibodies against SS-A/Ro antigen. Antibodies against SS-B/La are typical mainly for Sjögren’s syndrome (50-60%), particularly in extraglandular manifestations in lung, kidney, and liver. Anti-SS-B/La are positive in 15% of patients with systemic lupus erythematodes (SLE). The antibodies may be present a few years or some years before the disease starts. They are detected together with anti-SS-A/Ro antibodies in neonatal lupus.
Antibodies against SS-B/La as well as anti-Ro52 antibodies significantly increase a risk of congenital atrioventricular block (CAVB).
Antigen Used: Recombinant SS-B/La antigen.
Advantages
- Detection of anti-SS-B/La antibodies, IgG class
- Evaluating patients with signs and symptoms of a connective tissue disease and positive test for antinuclear antibodies
- A positive result for SS-A/Ro60 antibodies indicates connective tissue disease, including Sjögren’s syndrome and systemic lupus erythematodes (SLE)
- Intended for human serum and plasma
- Recombinant SS-B/La antigen is used
- The kits are CE-IVD certified and intended for professional use
- For each CLIA kit a corresponding control set is available
| Assay stability | 30 days in-board-stability / in-use-stability until the expiration date at storage temperature 2-8 °C |
| Sample matrix | Serum, Plasma |
| Sample volume | 10 µL |
| Measuring range | 0,5-320 U/ml |
| Assay/kit content | Reagent Cartridge with specific reagents for the assay, magnetic particles, calibrators |