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recomLine Tropical Fever

Line immunoassays for the detection of IgG or IgM antibodies
against Dengue (DENV), Chikungunya (CHIKV) and Zika virus (ZIKV) infections in human serum or plasma
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Mikrogen recomLine Tropical Fever tests are serological, qualitative line immunoassays that combine the diagnostic markers Equad proteins and non-structural proteins (NS1), thereby enabling the identification of specific antibodies against the individual antigens of Dengue, Chikungunya and Zika viruses. Virus-like particles (VLP) are used to detect CHIKV and NS1 and Equad proteins are used for DENV and ZIKV. The unique setup allows differentiation of DENV and ZIKV using a 2-step interpretation scheme that includes NS1 antigen reactions and, in their absence, reactivities against Equad proteins.

Products

recomLine Tropical Fever IgG
Reagents for 20 determinations
 Article no.: 7872 Request

recomLine Tropical Fever IgM
Reagents for 20 determinations
 Article no.: 7873 Request

Advantages

  • New antigens: higher sensitivity due to CHIKV VLP, DENV and ZIKV Equad as well as improved flavivirus differentiation
  • Simultaneous detection and differentiation of DENV, CHIKV and ZIKV infections in one step
  • Parallel detection of IgG and IgM enables monitoring of seroconversions and supports diagnosis of both primary and secondary flavivirus infections
  • Additional diagnostic support to reliably exclude ZIKV infections in pregnant women
  • For human serum/plasma from approximately 7 days after symptom onset and for follow-up samples after 1-2 weeks
  • Easy and clear interpretation due to two-band criterion
  • Partial and full automation, software-based evaluation (recomScan) and integration with laboratory information system possible
  • High sensitivity and specificity due to the use of recombinant antigens:
Antigen bands Description
DENV NS1 Dengue non-structural protein 1 (1st stage differentiation).
DENV Equad Variant d. dengue envelope protein with targeted mutations to increase specificity (2nd stage differentiation).
CHIKV VLP Chikungunya virus-like particles
ZIKV NS1 Zika non-structural protein 1 (1st stage differentiation).
ZIKV Equad Variant d. Zika envelope protein with targeted mutations to increase specificity (2nd stage differentiation).

Safe and reliable

Validity check by integrated, strip-specific cutoff and antibody class controls

Flexible and compatible

Combination of all Mikrogen line immunoassays possible - uniform processing and interchangeable reagents

High Standard

CE mark: CE marked and patent pending