CLIA Scl-70
The Scl-70 antigen is a type I DNA topoisomerase. It has a native molecular weight of 100 kDa. The enzyme is degraded to a protein of 70 kDa and less. Anti-Scl-70 antibodies bind to a native form of the antigen as well as to proteolysis products with lower molecular weights.
Presence of Anti-Scl-70 antibodies is a highly specific serological marker for diffuse of systemic scleroderma. They are present in 20-40% of individuals with systemic scleroderma. They indicate worse disease prognosis, and higher probability of musculoskeletal system and organ affections (lung fibrosis, proteinuria, heart damage). Anti-Scl-70 antibodies are rarely present in the localized forms of scleroderma. The antibody level corresponds with the disease activity.
Antigen Used: A mixture of native and recombinant Scl-70 antigens.
Products
| Product | Size | Article no. | |
|---|---|---|---|
|
50 Tests
|
Article no.: 71022 | Request |
Advantages
- Detection of anti-Scl-70 antibodies, IgG class
- Evaluating patients with clinical signs and symptoms compatible with systemic sclerosis and positive test for antinuclear antibodies
- Intended for human serum and plasma
- A mixture of native and recombinant Scl-70antigens used
- The kits are CE-IVD certified and intended for professional use
- For each CLIA kit a corresponding control set is available
| Assay stability | 30 days in-board-stability / in-use-stability until the expiration date at storage temperature 2-8 °C |
| Sample matrix | Serum, Plasma |
| Sample volume | 10 µL |
| Measuring range | 3-320 U/ml |
| Assay/kit content | Reagent Cartridge with specific reagents for the assay, magnetic particles, calibrators |