CLIA Uromodulin

Chronic kidney disease (CKD) represents a serious health problem affecting more than 10% of the global population. It often progresses silently, without obvious symptoms until advanced stages. Early detection is crucial for slowing disease progression and preventing severe complications such as the need for dialysis or transplantation. In clinical practice, although we have reliable indicators of glomerular filtration (e.g., creatinine or eGFR), we lack a marker for renal tubular function. Kidney damage often begins at the tubular level, not the glomeruli. If we monitor only glomerular function, the problem may be detected only in later stages.

Uromodulin (UMOD) is a specific protein produced exclusively by epithelial cells of the renal tubules. Whose concentration sensitively reflects the functional integrity of the tubular apparatus and enables detection of kidney damage even before eGFR declines. 

A decrease in Uromodulin concentration below a defined threshold signals reduced kidney function and can reveal CKD risk earlier than changes in traditional parameters such as creatinine.

CLIA Uromodulin can be quantified in serum with results available within 20 minutes. Due to its high specificity and sensitivity, it represents a reliable tool for prevention and early detection of kidney disease.