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Clia Centromere

Chemiluminescence kit for the detection of Centromere antibodies in human serum or plasma
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  6. CLIA Centromere

The centromere is the part of a chromosome that links sister chromatids. Centromere proteins may become a target for anti-centromere antibodies (ACA). Most frequently, the autoimmune reaction is directed against CENP A (17 kDa), CENP B (80 kDa), or CENP C (140 kDa). The CENP B is considered the most significant autoantigen from the group.

Antibodies to CENP B and CENP A are an important diagnostic marker for systemic sclerosis (scleroderma), found in 20-40% of patients. They are highly specific for the limited form of systemic sclerosis – CREST syndrome (calcinosis, Raynaud’s phenomenon, oesophageal motility abnormalities, sclerodactylia, and telangiectasia). Contrary, they are very rarely found in the diffusion form of the disease. The presence of ACA may predate the clinical diagnosis of CREST syndrome by up to several years. Their presence is prognostically significant in patients with Raynaud’s phenomenon. However, ACA have also been described in some patients with primary biliary cirrhosis and may occur in patients with rheumatoid arthritis or lupus erythematosus.

Antigen Used: Mixture of recombinant CENP B and CENP A antigens.

Products

CLIA Centromere
50 tests
 Article no.: 71023 Request

Advantages

  • Detection of anti-centromere antibodies (ACA), IgG class
  • Diagnosis of systemic sclerosis, highly specific for CREST syndrome
  • Evaluating patients with clinical signs and symptoms compatible with systemic sclerosis
  • Prediction of CREST syndrome
  • Prognostically significant in patients with Raynaud’s phenomenon
  • Intended for human serum and plasma
  • A mixture of recombinant CENP B and CENP A antigens used
  • The kits are CE-IVD certified and intended for professional use
  • For each CLIA kit a corresponding control set is available
Assay stability 30 days in-board-stability / in-use-stability until the expiration date at storage temperature 2-8 °C
Sample matrix Serum, Plasma
Sample volume 10 µL
Measuring range 0,5-320 U/ml
Assay/kit content Reagent Cartridge with specific reagents for the assay, magnetic particles, calibrators