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SS-A/Ro antigen is a ribonucleoprotein (RNP) complex localized in nucleus and cytoplasm. It consists of hYRNA (small cytoplasmic RNA) and two protein antigens of 52 kDa and 60 kDa (Ro52 and Ro60).
Autoantibodies against Ro60 a Ro52 are often found...
SS-A/Ro antigen is a ribonucleoprotein (RNP) complex localized in nucleus and cytoplasm. It consists of hYRNA (small cytoplasmic RNA) and two protein antigens of 52 kDa and 60 kDa (Ro52 and Ro60).
Autoantibodies against Ro60 a Ro52 are often found...
The Scl-70 antigen is a type I DNA topoisomerase. It has a native molecular weight of 100 kDa. The enzyme is degraded to a protein of 70 kDa and less. Anti-Scl-70 antibodies bind to a native form of the antigen as well as to proteolysis products with...
The U1-snRNP ribonucleoprotein complex, also known as Sm/RNP complex, belongs to a group of small nuclear ribonucleoproteins. In addition to other proteins and RNAs, the snRNP complex includes three proteins (RNP 68, RNP A and RNP C) specific for a...
Sm is a small nuclear ribonucleoprotein composed of several protein autoantigens designated B, B1, D, E, F, and G, which range in size from 11 kD to 26 kD. Sm is a part of the U1-snRNP ribonucleoprotein complex, also known as Sm/RNP complex. Sm (Smith)...
SS-B/La antigen is a phosphoprotein with molecular weight 48 kDa localized mostly in a complex with various RNA molecules in both the cell nucleus and the cytoplasm.
Autoantibodies against SS-B/La are rarely found by themeselves. They are more frequently...
Adiponectin together with Leptin, is one of the key adipokines produced by adipose tissue and its serum levels correlate with total body fat. Leptin plays an important role in energy metabolism, inflammatory processes and insulin sensitivity. Their...
Antibodies to double-stranded DNA (anti-dsDNA) fall in the group of antinuclear antibodies. Anti-dsDNA is included in the Systemic Lupus International Collaborating Clinics classification criteria (SLICC) for SLE and is also outlined in the classification...
Jo-1 antigen is a histidyl-tRNA synthetase enzyme localized mainly in the cytoplasm. It is a member of the amino acyl-tRNA synthetase family of enzymes found in all nucleated cells. Anti-Jo-1 antibodies are highly specific for myositis. They are...